Job Description

The Ghobrial lab is seeking a highly motivated Postdoctoral Fellow to lead investigations and conduct laboratory-based research focusing on multiple myeloma and its precursor conditions. Based on the mission of the lab, the successful candidate will be responsible for identifying novel biomarkers for tumor burden, tumor biology, and immune state in both the bone marrow and peripheral blood aiming to improve assessment for prognostication and monitoring of therapy response in patients with MGUS and SMM. In pursuit of these goals, they will leverage next-generation sequencing and advanced laboratory methods, including sterile tissue culture, proteomics, spatial proteomics/transcriptomics, and single-cell genomic characterization. In addition, the development of novel immunologic techniques and the application of new technologies will be key components of the effort and investigating the function of immune cells as key regulators of the tumor microenvironment. Collaboration with pathologists for tissue imaging correlations and with computational biologists is expected. The work will largely involve human tissues and samples for in vitro studies and modeling, with some potential animal work.The successful candidate will be highly organized, a team player, and able to work flexible hours to accommodate experimental needs. We are looking for a bright, motivated, and dedicated individual with strong scientific, organizational, and interpersonal skills.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Design, conduct, and troubleshoot hypothesis-testing experiments.? 
• Design, conduct, and validate high-throughput, hypothesis-generating screens.? 
• Mentoring of research technicians and undergraduate students.? 
• Maintain detailed and understandable lab notebooks and documentation.? 
• Interpret, discuss and present research findings with lab members and the principal investigator.? 
• Use computational approaches to analyze complex data sets, including next generation sequencing data sets, and/or effectively collaborate with computational biologists.? 
• Prepare figures and progress reports, write manuscripts and review articles, and present at scientific conferences.

• Ph.D. in Biology or M.D. with at least 2-3 years of laboratory experience technically proficient in basic wet lab techniques, including primary and cell line culture, viability assessment, cell cycle analysis, cytotoxicity, proliferation, migration analysis, PCR, Western blotting, cloning, etc.
  

• Strong background in cancer immunology, ideally with a focus on the hematopoietic system.
  
• The candidate is highly organized, collaborative, and flexible with experimental scheduling and demonstrates excellent scientific, interpersonal, and communication skills.
• Technical proficiency, scientific creativity, collaboration with others and independent thought.? 

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.

As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

EEOC Poster

About Dana-Farber Cancer Institute

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to under-served members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

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